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Description
Elevated levels of lactate in the TME hinder the export of lactate from human CTLs, consequently impeding the proliferation and cytotoxic effects of CTLs

It plays a role in the production of myelin, a protective covering of nerve fibers

At a median follow-up of 20.7 months, the addition of isatuximab to Kd yielded a statistically significant improvement in PFS (HR, 0.531

Lancet Oncol (2006) 7:51820
