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The functional repertoire of ATMs is broad and includes proliferation during adipose remodeling, regulation of fibrotic responses, antigen presentation to T cells, production of metabolic enzymes and mediators that shape stromal communication, modulation of adipocyte insulin sensitivity, and control of adipocyte progenitor activation

It randomized 220 outpatients with MDD to 40 mg/day, 80 mg/day, or placebo over 12 weeks, using a sequential-parallel comparison design to improve signal detection

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Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma