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In clinical practice, HCV genotype can be determined by various commercial kits, using direct sequence analysis of the 5' noncoding region (Trugene 5'NC HCV Genotyping Kit, Bayer HealthCare, Diagnostics Division, Tarrytown, New York) or reverse hybridization analysis using genotype-specific probes located in the 5' noncoding region (commercialized as INNO-LiPA HCV II, Innogenetics, Ghent, Belgium, or Versant HCV Genotyping Assay, Bayer HealthCare) [10-13 ]