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Similar content being viewed by others Introduction Metabolic profiles of human blood provide valuable information about in vivo physiological states, which are influenced by genetic, epigenetic, physiological, and life-style factors 1,2,3

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Additionally, genetic factors, including mutations in APP, presenilin 1 (PSEN1), and presenilin 2 (PSEN2), as well as the 4 allele of apolipoprotein E (APOE4), increase the risk of AD by influencing amyloid and tau pathology (Karran and De Strooper 2016 )