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GSH depletion enhances peroxynitrite toxicity and tissue injury during circulatory shock (258, 278), and a relationship between GSH depletion and enhanced peroxynitrite toxicity has also been proposed as contributing to the development of some neurodegenerative diseases such as Parkinsons disease and amyotrophic lateral sclerosis (847, 1321)

Glutathione plays a vital role in detoxifying the liver by neutralizing toxins, heavy metals, and other harmful substances

this finding seems to suggest a widespread impairment of the glutathione system in patients with epilepsy, independently from the location of the epileptogenic focus

[1] [2] Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist