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Importantly, persistent activation of NRF2 that is induced pharmacologically in KEAP1-NRF2-intact cancer cells also decreases NEAA synthesis and makes them rely on exogenous NEAAs (LeBoeuf et al
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[DOI] [PubMed] [Google Scholar] 94.Hamilton, M
This divergence in clinical course parallels has been observed in human influenza, in which young persons without significant comorbidities tend to recover by Day 7, whereas older persons with comorbidities often clinically deteriorate
