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M.GeneidiA

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the Ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

The next important group of H 2 S prodrugs, some of which entered the clinical phase, includes H 2 S-releasing modifications of many clinically used drugs with the well-known ATB-346 which is a H 2 S-releasing derivative of naproxen [170,171] (Figure 12)

Additionally, high expression of VEGF in GBM is correlated with poor prognosis (Fig