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The IGNITE network, funded by the NIH, is conducting a large multicenter randomized pragmatic trial to determine the effect of CYP2D6-guided opioid prescribing on chronic pain and post-operative pain control and opioid usage[163]

The human genome harbours twenty-five selenoprotein genes, of which eight GPx paralogues have been identified, namely GPx1 (locus 3p21.3), GPx2 (locus 14q24.1), GPx3 (locus 5q23), GPx4 (locus 19p13.3), GPx5 (locus 6p22.1), GPx6 (locus 6p22.1), GPx7 (locus 1p32) and GPx8 (locus 5q11.2) (Reference Zmorzyski, widerska-Koacz and Koczkodaj125)

This may be of particular relevance for the recovery of glaucoma (episcleral vein cauterization) [11] (i.e., rapid decrease in the increased intraocular pressure and preserved retinal integrity) [11], along with the recovery of pupil function [12], retinal ischemia [13], and corneal injuries (i.e., those induced by complete corneal abrasion [14], corneal ulcer [15], or dry eye [16,17])
