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Especially in UPR, although TMAO can selectively activate PERK-mediated UPR by binding to PERK, this does not explain TMAO-mediated aggregation of unfold or misfolded proteins in AD
The signaling pathway of necroptosis has been largely elucidated [207]
SCFAs that are absorbed into the circulation, especially acetate and propionate, are oxidized in the liver and skeletal muscle and may play a role in appetite regulation (7, 36, 37)
