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Proper encapsulation technology is a highly complex method to incorporate a hydrophilic nutrient into a lipid carrier as they normally repel each other

Availability of Data and Materials The datasets generated during the current study are available from the corresponding author on reasonable request

10.1016/j.cell.2015.04.042 Summary Keywords intervertebral disc, low back pain, MSC, regenerative medicine, microenvironment, niche, extracellular vesicles (EVs), disc progenitor cells Citation Wang H, Xu A, Hua W, Mao J, Zhang J, Ma X and Lu L (2025) Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions