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PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)
Novaes, G
doi: 10.1016/j.abb.2006.11.021
Conditions such as idiopathic pulmonary fibrosis (IPF), pneumonia and COPD are characterized by excessive inflammation and depleted glutathione levels
