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Of these, 6 (38%) experienced an irAE, with only 1 (6%) having a flare of the underlying rheumatologic disease 81

This effect may be due to the upregulation of antioxidant stress genes, including superoxide dismutase 1 (SOD1) and dual oxidase 1 [8]
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Musso, G., Cassader, M., Paschetta, E
