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Importantly, CoQ10 exist in diverse membranes throughout cells, not just in mitochondrial, indicating that CoQ10 serves as a universal endogenous mechanism for protecting against lipid peroxidation [48]

It acts primarily as an enzymatic cofactor for the transport of long-chain fatty acids from the cytoplasm into the mitochondria, and subsequent degradation to beta-oxidation, being a very important energy metabolism pathway

However, patients without hepatic metastasis had better ORR than patients with hepatic metastasis, indicating that ipi/nivo alone is not enough for LMUM [89]

The nervous system is made up of two primary components: the central nervous system (CNS), and the peripheral nervous system (PNS)