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Histologically, chronic pefloxacin treatment increased the ratio of cells with round nuclei, a phenomenon seen in tendinopathy (Figures 4D, E)

Picillo M, Lizarraga KJ, Friesen EL, Chau H, Zhang M, Sato C, Rooke G, Munhoz RP, Rogaeva E, Fraser PE, Kalia SK, Kalia LV (2018) Parkinsonism due to A53E -synuclein gene mutation: clinical, genetic, epigenetic, and biochemical features

J.DeveauM.PlunkettL.et al (2010)
Downstream of Rac1 in actin polymerization, mutations in PAK s and WASF1 can cause macrocephaly, seizures, intellectual disability, or ASD (Zamboni et al., 2018