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doi: 10.1105/tpc.16.00613 10 ChaeH
This energy supply supports excitability, biosynthesis of neurotransmitters, synaptic transmission and plasticity (reviewed by (Dienel, 2012))
Interestingly, although lipid peroxidation amplifies PARP-1 activation, inhibiting PARP-1 can significantly reduce lipid peroxidation and maintain mitochondrial integrity, underscoring the link between PARP-1 overactivation and oxidative damage in promoting parthanatos [142, 143]
Lee S-T, Jeon D, Chu K, Jung K-H, Moon J, Sunwoo J, et al
