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Description
The absence of leg cramps from official labeling does not definitively rule out a connection, as post-marketing experience sometimes reveals adverse effects not detected in pre-approval trials due to sample size limitations, duration of follow-up, or patient population differences

Practitioners should consider specific B 12 dietary counselling for patients currently on a vegetarian, or vegan diet, including patients who have recently initiated such a diet

In glioma, numerous clinical studies collectively show that anti-angiogenic treatment can prolong progression-free survival but fails to improve overall survival [293]

Most practitioners recommend 12-16 week cycles followed by a 2-4 week assessment break
