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8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

This is the reason for the popularity of liming ( Use of Acid-Tolerant Crop Varieties In acidic soils some plants are more tolerant than others, with variation even among genotypes of the same species