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doi: 10.1093/mp/ssn078

Similar content being viewed by others Introduction Glutathione (GSH) deficiency is one of the earliest biochemical perturbations in Parkinsons disease (PD), 1,2 leading to the hypothesis that GSH supplementation may have therapeutic value in alleviating PD symptoms or modifying progression

The choice to analyze the intracellular protein concentrations of IL-1B and CCL3 was based on the premise that the inhibition of gene transcription in response to B12 added to the turnover of these proteins by the proteasome machinery present inside the cells would result in detectable reductions in their concentrations after 24 hours of culture incubation

Concentrations of 10-20mg/ml work well, requiring 0.05-0.3ml injection volumes that standard insulin syringes measure accurately