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Over time, repeated exposure can impair cognitive function, slow metabolism, and heighten inflammation
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The main novel findings in the study include 1) activation D1/D5 receptor can activate SK1-3 channels through cAMP-PKA signaling, 2) activation of SK1-3 channels caused by D1/D5 receptor can be mediated by NADPH-ROS signaling, 3) activation of D1/D5 receptor and SK1-3 channels can suppress NO production via increasing ROS rather than the cell membrane potential
