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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis Through Reduced Heme Oxygenase-1 (HO-1) Levels
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Choice B: Effective penetration into the liver is a necessary pharmacokinetic property for drugs treating hepatic infections

The combined effects of ionic imbalance and elevated ROS levels cause multiple deleterious impacts culminating in fungal cell death (Phillips et al., 2003