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otherwise, these ROS can damage the essential constituents of plants and ultimately lead towards PCD
112 More recently, it was suggested that methotrexate causes ferroptosis through activation of autophagy, leading to increased degradation of ferritin and liberation of ferrous iron (ferritinophagy), which promotes LPO and liver injury
26 In addition, the activity of the cytochrome P450 reductase (POR) also requires NADPH, which has a major role in the metabolism of drugs, xenobiotics, and steroid hormones
10.1113/expphysiol.1997.sp004024 103 SiesH
