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This distinct form of cell death, characterized by iron-dependent phospholipid peroxidation, is influenced by various cellular metabolic processes, including redox balance, iron metabolism, mitochondrial function, and the metabolism of amino acids, lipids, and carbohydrates, alongside numerous signaling pathways pertinent to various diseases ( Recent studies indicate a correlation between ferroptosis and the emergence of female reproductive disorders, such as polycystic ovary syndrome, premature ovarian insufficiency, endometriosis, ovarian cancer, preeclampsia, and spontaneous abortion

10.1006/geno.2001.6554 Genomics 126 WitteI.AltenhoferS.WilgenbusP.AmortJ.ClementA

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Furthermore, duloxetine and milnacipran have not been found to improve health-related quality of life scores more than placebo