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It inhibits the enzyme that produces melanin, which reduces pigmentation at the source

Related B Vitamins and Methylation MTHFR (folate) Choline (PEMT) Vitamin B12 (MTR, MTRR) Riboflavin (cofactor in methylation) Vitamin B6 Vitamin B5 (Pantothenic acid) Creatine (Takes the strain off the methylation cycle) COMT (Affects response to methylated vitamins) Related Articles and Topics: References: Daz-Muoz C, Bozzarelli I, Lopera-Maya EA, et al Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility Gut Published Online First: 20 January 2026

Decreases Joint Pain

In one of these non-P-gp MDR lines, the H69AR small cell lung carcinoma line found amplification and increased expression of a novel gene, the MRP (Cole et al., 1994)