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Fatigue is a commonly reported symptom in people with AS

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Clin Endocrinol 40:383391 Hansen TB, Brixen K, Vahl N, Jrgensen JO, Christiansen JS, Mosekilde L, Hagen C (1996) Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study

If bowel transit and microbiome balance are poor, hormones recirculate improperly, metabolic inflammation increases, and many interventions fail to stick
