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Description
In RA pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit proliferative features similar to tumor cells and subsequently cause cartilage erosion, which will eventually lead to joint destruction ( It has been hypothesized that iron is excessively accumulated in the synovium of RA patients to perpetuate inflammation ( 2 Overview of ferroptosis Cell death is a fundamental physiological process in all aspects of life
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doi: 10.3390/encyclopedia2020063, 43
Moreover, the aberrant OXPHOS complexes are also involved in mitochondria dysfunction
