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Clinical Guidelines & Documentation

Many solid tumors show little to no response to ICIs or develop acquired resistance, largely due to the immunosuppressive state of the tumor microenvironment, often referred to as cold tumors [356]
To analyze which cellular processes are affected by expression of SnCE1 and to confirm the subcellular localization of SnCE1 in human cells we next performed microscopy of HeLa cells transiently expressing full length SnCE1, i.e., SnCE1 fl , as well as truncated SnCE1 74-310 , i.e., SnCE1 trunc (Figs

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