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Stuart Pape, Chad Landmon, Michael Gaba, Claire Davies and Suzanne Bassett provide a summary of the notice and the implications for bulk compounders: To view or add a comment, sign in The FDA, after reviewing nominations for semaglutide, tirzepatide and liraglutide, has found no demonstrated clinical need for outsourcing facilities to compound these drugs from bulk substances

Storage After Reconstitution Do This Store in refrigerator at 36-46F (2-8C) Keep away from light (store in box if possible) Use within 28-60 days of reconstitution Inspect for particles before each use Always swab the stopper before drawing Never Do This Never freeze reconstituted retatrutide Don't leave at room temperature for extended periods Don't use if solution is cloudy or has particles Don't use past the expiration date Never share vials or needles Stability note: While some sources cite 60-day stability, 28 days is the more conservative recommendation for compounded peptides

In late 2023, the FDA moved 17 bulk drug substances into Category 2 of its 503A Bulks List, including several popular peptides