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It has also been described that the CD38-NAD + axis controls metabolic reprogramming of T cells in the tumor microenvironment and contributes to drug resistance plaguing PD-1/PD-L1checkpoint inhibitors

Specifically, this peptide seemed to suppress the growth of two types of cancer cells in experimental settings: SH-SY5Y neuroblastoma cells, which are a model for studying nerve cell behavior and pathology, and U937 histiocytic lymphoma cells, which are used to study the immune system's response to cancer