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Additionally, in LPS-activated primary microglia cells, PQQ decreased the nuclear trafficking of NF-B and dephosphorylate p65, p38, and JNK in MAPK pathways

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However, in aralar / animals de-amidation of glutamine in neurons may be impaired as will be discussed below, which may prevent glutamine synthesis in astrocytes

Future research should aim to clarify the specific molecular pathways involved, establish dependable biomarkers for early detection, and investigate new therapeutic targets to enhance patient outcomes
