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Additionally, the antioxidant activity of herbs and spice extracts, measured by three methods (DPPH, ABTS and FRAP), varies depending on the time of extraction (30 min or 24 h) and solvent used (water, 50% ethanol in water or ethanol) (Muzolf-Panek and Stuper-Szablewska, 2021)

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[78] reported that fisetin can ameliorate type 2 diabetes-related vascular aging by targeting the PI3K/Akt/Bcl-2/Bcl-xl axis, promoting apoptosis of senescent endothelial cells, suppressing SASP factors, and enhancing the therapeutic efficacy of metformin, though direct dose equivalence and mechanistic comparisons were not established

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