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However, due to lifestyle factors such as limited sun exposure and dietary insufficiencies, many individuals experience Vitamin D deficiency, which can manifest as fatigue, depression, and weakened immune response

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METHIONINE METABOLISM Methionine is an important donor of a methyl group in several single-carbon transfer reactions and of the sulfur atom in the synthesis of the non-essential amino acid cysteine

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Since it is well known that GSH depletion leads to the upregulation of antioxidant genes, many of which are under Nrf2 control and, that in several types of tumors, Nrf2 is constitutively activated [122, 123], a new and indirect approach for cancer therapy may be used to modulate the Nrf2-ARE pathway

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