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[2] As a nutraceutical ingredient, AOD-9604 has been evaluated under Generally Recognized as Safe (GRAS) frameworks, and its pharmacological profile continues to inform mechanistic studies examining the intersection of lipid metabolism, adipose tissue biology, and peptide pharmacology

Biomarkers correlating the lower IGF-1 concentration to increased waist-to-hip ratio or to impaired glucose tolerance are also being studied [224, 225]

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5,6 Levels of 151240 pmol/L are considered borderline deficiency and may be associated with depression and cognitive decline