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The rate constants from our deglutathionylation assays between 6.4 10 4 and 1.4 10 6 M 1 s 1 are very similar to the rate constants for PfGrx or plant and mammalian glutaredoxins from discontinuous or coupled enzymatic assays with other high and low molecular weight GSSR substrates (Table 1) 9,11,14,19 , thus confirming our assay as an alternative reliable method for the direct analysis of enzyme-catalyzed deglutathionylations

Bridging that translational gulf demands a sharper focus on three interlocking realities: cost-effectiveness, real-world scalability, and sustained patient adherence

Unfortunately, there will also be too many potential combinations of biologics to permit exhaustive evaluation of each possible combination

Participants with hepatic impairment were allocated into three groups, with the degree of impairment categorised by the investigator according to ChildPugh criteria: mild (Grade A
